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LEPROSY
NATUREEDUCATIONARTLEPROSY

The Turing Foundation aims at the elimination of leprosy as a disfiguring disease and supports scientific research into diagnosing and curing the desease, and preventing its spread.
Leprosy is a cruel, disfiguring disease which strikes almost exclusively the poorest of the poor (to such extent that people in richer countries are often unaware that the disease still exists). Its victims hardly ever die as a result of it, but leprosy often leads to loss of hands or feet or loss of sight. Leprosy has an incubation period of many years. A key challenge is to detect the disease in an early stage and to treat it before it infects others and before nerve damages have become irreparable.

The Turing Foundation focuses on scientific research in the area of diagnostics and treatment of leprosy.
Most recent projects:
Randomised controlled trials of methotrexate in Erythema Nodosum Leprosum
April 2021
ENLIST Randomised controlled trials of methotrexate in Erythema Nodosum Leprosum, 2021-2022
Erythema Nodosum Leprosum (ENL) is a serious and very painful leprosy complication. It is... more
M. Leprae bacterie
April 2021
Extra clofazimine for MB cases at high risk of ENL reactions, 2021-2023
Erythema Nodosum Leprosum (ENL) is a serious and very painful leprosy complication. The disease can be... more
M. Leprae bacterie
April 2021
Immunomodulation by Mycobacterium Indicus Pranii (MIP) in MB leprosy, 2021-2023
Leprosy patients can be effectively treated with multi-drug treatment (MDT), but they are still... more
M. Leprae bacterie
April 2021
MetLep Trial: Metformin as adjunct therapy for MB leprosy, 2021-2023
Metformin is a cheap and safe medicine which has been used to treat diabetes for a long time. Research into... more
Molecular Methods in Subclinical Models of Leprosy to Test PEP
January 2021
Molecular Methods in Subclinical Models of Leprosy to Test PEP, 2021-2022
Whilst multi-drug therapy has been very successful in reducing the global prevalence of leprosy, new cases... more
Point-of-care tests for leprosy in South America, 2021-2024
January 2021
Point-of-care tests for leprosy in South America, 2021-2024
The Leiden University Medical Center (LUMC) team has developed a simple diagnostic test in previous studies. This... more
M. Leprae bacteria
January 2021
Contribution to the leprosy research department of Netherlands Leprosy Relief, 2020-2021
The Turing Foundation has been co-financing projects related to the fight against leprosy... more
Dapsone Hypersensitivity Syndrome Biomolecular Predictive Test, Papua and Nepal
January 2021
Dapsone Hypersensitivity Syndrome Biomolecular Predictive Test, Papua and Nepal, 2021
Leprosy is treated with a combination of three drugs: dapsone, rifampicin and clofazimine.... more
LepVax: safety and vaccin-induced immune response, Brazil, 2019-2021
January 2021
LepVax: safety and vaccin-induced immune response, Brazil, 2021
Researchers from the Infectious Disease Research Institute (IDRI), in collaboration with the America Leprosy Mission... more
Monitoring the effect of prophylactic interventions in contacts of leprosy patients including field-application of a novel immunodiagnostic test, Bangladesh
January 2021
Novel immunodiagnostic interventions and diagnostic tests for leprosy, Bangladesh, 2021
This sudy by Leiden University Medical Centre and Erasmus University Rotterdam is focused on... more
Scientific Research
London School of Hygiene and Tropical MedicineLeprosy Research Initiative ENLIST Randomised controlled trials of methotrexate in Erythema Nodosum Leprosum, 2021-2022
Erythema Nodosum Leprosum (ENL) is a serious and very painful leprosy complication. It is often chronic and causes serious morbidity, not only affecting the skin but also bones, joints, eyes, nerves, testes, and kidneys. Effective treatment for ENL is available but expensive, has considerable side-effects, and is often inaccessible in many countries where leprosy is endemic. Methotrexate is cheap and has been used all over the world to treat conditions like psoriasis since the 1950s. This medicine is possibly an effective alternative to prednisolone (the most widely used corticosteroid treatment for ENL). The London School of Hygiene and Tropical Medicine will validate this by inviting patients with ENL in Bangladesh, Brazil, Ethiopia, India, Indonesia, Nepal and the Philippines to take part in a study where some patients are prescribed methotrexate, and others prednisolone.

The Turing Foundation is contributing €350,000 towards this research (€25.000 in 2021).

See also: Leprosy Research Initiative: other projects

Randomised controlled trials of methotrexate in Erythema Nodosum Leprosum
Randomised controlled trials of methotrexate in Erythema Nodosum Leprosum



Bombay Leprosy ProjectLeprosy Research Initiative Extra clofazimine for MB cases at high risk of ENL reactions, 2021-2023
Erythema Nodosum Leprosum (ENL) is a serious and very painful leprosy complication. The disease can be treated with the drug clofazimine. This research project aims to evaluate whether treating leprosy patients with extra clofazimin reduces the severity and frequency of ENL and whether it prevents nerve damage over a 24-month period. The Bombay Leprosy Project research is being conducted in Bangladesh and India.

The Turing Foundation is contributing € 100,000 towards this project (of which, € 23,000 in 2021).

See also: Leprosy Research Initiative: other projects

M. Leprae bacterie
M. Leprae bacterie



National Institute of Research in Tribal HealthLeprosy Research Initiative Immunomodulation by Mycobacterium Indicus Pranii (MIP) in MB leprosy, 2021-2023
Leprosy patients can be effectively treated with multi-drug treatment (MDT), but they are still susceptible to being reinfected with leprosy. It has been demonstrated that the MIP (Mycobacterium indicus pranii) vaccine can teach the immune system to activate an immune response when it encounters M. leprae. This process is called 'immune modulation'. The National Institute of Research in Tribal Health (ICMR) in India uses advanced techniques to investigate the cells involved in an immune response and the differences between MIP-vaccinated and unvaccinated patients. The research aims to better understand the underlying mechanism of immune response and immune modulation, and use the knowledge gained to fight leprosy more effectively.

The Turing Foundation is contributing € 94,000 towards this project (of which, € 27,700 in 2021).

See also: Leprosy Research Initiative: other projects

M. Leprae bacterie
M. Leprae bacterie



IOCRLFaculty of Medicine University of IndonesiaLeprosy Research Initiative MetLep Trial: Metformin as adjunct therapy for MB leprosy, 2021-2023
Metformin is a cheap and safe medicine which has been used to treat diabetes for a long time. Research into tuberculosis patients, which is caused by a bacterium similar to leprosy, has demonstrated that metformin has a beneficial effect on the immune system. The IOCRL (Universities of Indonesia and Oxford Clinical Research Laboratory) is investigating the extent to which treatment of leprosy with metformin can reduce the degree and severity of leprosy reactions and prevent its consequences. The research is being conducted in Indonesia.

The Turing Foundation is contributing € 100,000 towards this project (of which, € 26,500 in 2021).

See also: Leprosy Research Initiative: other projects

M. Leprae bacterie
M. Leprae bacterie



National Hansen's Disease ProgramsLeprosy Research Initiative Molecular Methods in Subclinical Models of Leprosy to Test PEP, 2021-2022
Whilst multi-drug therapy has been very successful in reducing the global prevalence of leprosy, new cases still occur. This indicates that leprosy transmission is still taking place despite effective treatment. Treating individuals known to have been exposed to leprosy, also known as post exposure prophylaxis (PEP), can reduce the number of subclinical infections and transmission of the disease. This study will evaluate different PEP treatments and provide experimental evidence on the level of effectiveness. The goal is to determine the most effective PEP treatment regardless of the host's level of immune functionality.

This study by National Hansen's Disease Programs builds on a previous study by the same group, which also received funding from the Turing Foundation.

The Turing Foundation is contributing €36,500 towards this NHDP project (of which, €25,000 in 2021). The Leprosy Research Initiative is matching this contribution.

See also:
      National Hansen's Disease Programs: other projects
      Leprosy Research Initiative: other projects

Molecular Methods in Subclinical Models of Leprosy to Test PEP
Molecular Methods in Subclinical Models of Leprosy to Test PEP



LUMCLeprosy Research Initiative Point-of-care tests for leprosy in South America, 2021-2024
The Leiden University Medical Center (LUMC) team has developed a simple diagnostic test in previous studies. This point-of-care (POC) test uses a finger prick to determine whether and to what extent someone is infected with leprosy. The test can be performed by primary health care workers without complicated laboratory techniques. The LUMC is going to expand the use of the POC test to populations in Brazil and Bolivia, and investigate how the test functions in a Latin American population. The results will be compared with the previous studies in Bangladesh. This study builds on previous studies which also received funding from the Turing Foundation.

The Turing Foundation is contributing €152,742 towards this LUMC project (of which, €53,529 in 2021). The Leprosy Research Initiative is matching this contribution.

See also:
      LUMC: other projects
      Leprosy Research Initiative: other projects

Point-of-care tests for leprosy in South America, 2021-2024
Point-of-care tests for leprosy in South America, 2021-2024



Leprastichting Contribution to the leprosy research department of Netherlands Leprosy Relief, 2020-2021
The Turing Foundation has been co-financing projects related to the fight against leprosy with Netherlands Leprosy Relief for years. On top of this, every year we donate 5% of the total sum of these donations directly to Netherlands Leprosy Relief as a contribution towards the overhead costs it incurs as a member of the Leprosy Research Initiative: the international partnership for financing leprosy research.

In 2020 the Turing Foundation contributed a total of € 209,472 towards six studies into early diagnosis of leprosy. This means that our contribution towards Netherlands Leprosy Relief's overhead costs in 2020 has been set at € 10,474.

See also: Leprastichting: other projects

M. Leprae bacteria
M. Leprae bacteria



Institute of Health Research and Development of PapuaLeprosy Research Initiative Dapsone Hypersensitivity Syndrome Biomolecular Predictive Test, Papua and Nepal, 2021
Leprosy is treated with a combination of three drugs: dapsone, rifampicin and clofazimine. People with dapsone allergy develop what is called dapsone hypersensitivity syndrome (DHS). DHS is associated with skin disorders and organ failure, leading to the death of about 10% of DHS patients. The highest prevalence is found in east Asia. Earlier studies found a genetic mutation associated with a greatly increased risk of DHS. This study is investigating the use of a screening test which can determine whether someone has this genetic mutation. Leprosy patients who test positive will not be given dapsone, which will reduce the number of DHS cases.

The Turing Foundation is contributing € 76,661 towards this project by the Microbiology Department, Institute of Health Research and Development, Papua (of which € 24,000 in 2021). The Leprosy Research Initiative is contributing an equal sum.

See also: Leprosy Research Initiative: other projects

Dapsone Hypersensitivity Syndrome Biomolecular Predictive Test, Papua and Nepal
Dapsone Hypersensitivity Syndrome Biomolecular Predictive Test, Papua and Nepal



Infectious Disease Research InstituteLeprosy Research InitiativeAmerica Leprosy Mission LepVax: safety and vaccin-induced immune response, Brazil, 2021
Researchers from the Infectious Disease Research Institute (IDRI), in collaboration with the America Leprosy Mission (ALM), have developed a leprosy specific vaccine called LepVax. This vaccine has both prophylactic properties (preventing leprosy) and immunotherapeutic properties (treating leprosy reactions). That means that LepVax should prevent further development of the disease, both deformities after infection and new infections. This study is focused on testing the safety of and immune response to LepVax. The project includes collaboration with a clinic for leprosy research in Brazil (FioCruz).

The Turing Foundation has already contributed € 200,000 towards the earlier phases of this research, and is contributing € 175,000 towards this follow-up research (of which € 40,000 in 2021). The Leprosy Research Initiative is contributing an equal sum.

See also:
      Infectious Disease Research Institute: other projects
      Leprosy Research Initiative: other projects

LepVax: safety and vaccin-induced immune response, Brazil, 2019-2021
LepVax: safety and vaccin-induced immune response, Brazil, 2019-2021



LUMCErasmus Universiteit RotterdamLeprosy Research Initiative Novel immunodiagnostic interventions and diagnostic tests for leprosy, Bangladesh, 2021
This sudy by Leiden University Medical Centre and Erasmus University Rotterdam is focused on determining the long-term effect of the BCG vaccination on leprosy patients. New blood samples and new biomarker profiles are being used for this purpose. The second aim of the study is to test the effect of the antibiotic rifampicin on preventing leprosy from developing in new leprosy patients' contacts. Blood will be taken from these contacts at different times with a finger prick over the course of the study. The third and final goal of the study is to introduce the test as part of the national leprosy programme and train health centre staff to perform the test.

The Turing Foundation has contributed approximately € 1,700,000 towards IDEAL/INDIGO research in recent years, and is contributing more than € 112,500 towards this follow-up research in the period 2019-2021. The Leprosy Research Initiative is contributing an equal sum.

See also:
      LUMC: other projects
      Erasmus Universiteit Rotterdam: other projects
      Leprosy Research Initiative: other projects

Monitoring the effect of prophylactic interventions in contacts of leprosy patients including field-application of a novel immunodiagnostic test, Bangladesh
Monitoring the effect of prophylactic interventions in contacts of leprosy patients including field-application of a novel immunodiagnostic test, Bangladesh



Infectious Disease Research InstituteLeprosy Research Initiative IDRI: Integration of rapid diagnostic tests to facilitate earlier diagnosis and simplified case management of Leprosy, 2019
The Infectious Disease Research Institute (IDRI) is doing research on the island of Cebu in the Philippines into the effectiveness of two new leprosy tests. The project aims to detect leprosy at an early stage in leprosy patients' contacts and to better monitor the progression of the disease in leprosy patients being treated. In the earlier phase of the study, blood was collected from leprosy patients and their contacts using a finger prick. This group is being followed and screened for a period of 4 years. The Turing Foundation already contributed €140,000 towards the earlier phase of this research and is contributing €55,988 towards the final phase (2018-2019).

See also:
      Infectious Disease Research Institute: other projects
      Leprosy Research Initiative: other projects

IDRI: Integration of rapid diagnostic tests to facilitate earlier diagnosis and simplified case management of Leprosy
IDRI: Integration of rapid diagnostic tests to facilitate earlier diagnosis and simplified case management of Leprosy



Schieffelin Institute of HealthLeprastichting Identification of leprosy associated immune signatures that aid as early signals for determination of type I and type II reactions in leprosy, Karigiri, India, 2019
Early recognition and treatment of leprosy reactions helps prevent nerve damage and disfigurement. The Schieffelin Institute of Health (SIHR) is developing a laboratory test for early diagnosis of type I and type II leprosy reactions. Genetic material from blood and skin biopsies from leprosy patients are used to determine which genes differ in function between patients with and without leprosy reactions, and also which gene expression patterns possibly play a role in eliciting leprosy reactions in the skin, and the nervous system. These genes and associated proteins they encode are being used to develop the laboratory test. In addition, the level of cytokines, chemokines, growth factors and antimicrobial peptides in the blood are estimated, and research is being conducted in order to see whether diagnostic conclusions can be drawn.

The Turing Foundation is contributing €73,838 towards this research.

See also: Leprastichting: other projects

Identification of leprosy associated immune signatures that aid as early signals for determination of type I and type II reactions in leprosy, Karigiri, India, 2016-2019
Identification of leprosy associated immune signatures that aid as early signals for determination of type I and type II reactions in leprosy, Karigiri, India, 2016-2019





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