The Turing Foundation - Projects in <IMG SRC=kader/flag_ethiopia.gif WIDTH=72 HEIGHT=48 ALT="Ethiopia" ALIGN=LEFT style="margin-right:16px; margin-bottom:12px; border:0px;"> Ethiopia

Projects in

Ethiopia

LEPROSY ENLIST Randomised controlled trials of methotrexate in Erythema Nodosum Leprosum, 2016-2025
Erythema Nodosum Leprosum (ENL) is a serious and very painful leprosy complication. It is... more

LEPROSY Research on treatment of early neuropathy in leprosy 2014-2017
The TENLEP Research Consortium (Treatment of Early Neuropathy in Leprosy) is a large international association in... more

Also see:: Bangladesh, Benin, Brazil, Burkina Faso, Cambodia, Cameroon, D.R. Congo, Ethiopia, Ghana, Guinea, Guinea Bissau, India, Indonesia, Kenya, Liberia, Madagascar, Mali, Mozambique, Nepal, Netherlands, Niger, Papua, Papua New Guinea, Philippines, Sierra Leone, Spain, Tanzania, Togo
Also see country overview...

Project details


	ENLIST Randomised controlled trials of methotrexate in Erythema Nodosum Leprosum, 2016-2025 Erythema Nodosum Leprosum (ENL) is a serious and very painful leprosy complication. It is often chronic and causes serious morbidity, not only affecting the skin but also bones, joints, eyes, nerves, testes, and kidneys. Effective treatment for ENL is available but expensive, has considerable side-effects, and is often inaccessible in many countries where leprosy is endemic. Methotrexate is cheap and has been used all over the world to treat conditions like psoriasis since the 1950s. This medicine is possibly an effective alternative to prednisolone (the most widely used corticosteroid treatment for ENL). The London School of Hygiene and Tropical Medicine will validate this by inviting patients with ENL in Bangladesh, Brazil, Ethiopia, India, Indonesia, Nepal and the Philippines to take part in a study where some patients are prescribed methotrexate, and others prednisolone. The Turing Foundation is contributing €350,000 towards this research (€25.000 in 2024). See also: Leprosy Research Initiative: other projects Other projects in Brazil Other projects in Bangladesh Other projects in India Other projects in Indonesia Other projects in Nepal Other projects in Philippines Randomised controlled trials of methotrexate in Erythema Nodosum Leprosum
	Research on treatment of early neuropathy in leprosy 2014-2017 The TENLEP Research Consortium (Treatment of Early Neuropathy in Leprosy) is a large international association in which 14 researchers from renowned research institutes all over the world work together, combining their expertise in the field of leprosy-related inflammation of the nerves. TENLEP Trial is a large-scale research project focussing on nerve damage caused by leprosy. Its central research questions are: 1. To what extent can treatment of sub-clinical nerve damage reduce the number of patients with permanent nerve function impairments? 2. What is the most effective treatment for patients who have a clinical nerve function impairments? A random double blind research method was designed to find the answers to these questions, including two integrated trials. In these trials, a corticosteroid treatment of sub-clinical nerve damage will be tested (during sixteen weeks and six months). Dependent on the type of nerve damage, patients will participate in one of the two trials. Subsequently, all patients will be categorized randomly into a group getting treatment and a group receiving a placebo. The effect of the leprosy treatment will be measured within 6, 12, and 18 months after it has started. Various advanced electronic devices, measuring factors such as nerve conductivity and sense of temperature, will be used to monitor the effect of treatment as meticulously as possible. Apart from that, the measuring will be done by means of an activity scale. A comparison between the results of the groups getting either treatment or a placebo must make clear which type of treatment reduces the risk of permanent nerve damage as much as possible. The research will be conducted in the Netherlands, England and the largest leprosy endemic countries (Indonesia, India, the Philippines, Bangladesh, Brasil and Ethiopia). The Turing Foundation contributes € 742,847 to this research project (approx. 50% of the total research budget). See also: Other projects in India Other projects in Bangladesh Other projects in Philippines Other projects in Brazil Other projects in Indonesia Scanning Electron Microscopy of M. leprae

top