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ENLIST Randomised controlled trials of methotrexate in Erythema Nodosum Leprosum, 2016-2025
Erythema Nodosum Leprosum (ENL) is a serious and very painful leprosy complication. It is often chronic and causes serious morbidity, not only affecting the skin but also bones, joints, eyes, nerves, testes, and kidneys. Effective treatment for ENL is available but expensive, has considerable side-effects, and is often inaccessible in many countries where leprosy is endemic. Methotrexate is cheap and has been used all over the world to treat conditions like psoriasis since the 1950s. This medicine is possibly an effective alternative to prednisolone (the most widely used corticosteroid treatment for ENL). The London School of Hygiene and Tropical Medicine will validate this by inviting patients with ENL in Bangladesh, Brazil, Ethiopia, India, Indonesia, Nepal and the Philippines to take part in a study where some patients are prescribed methotrexate, and others prednisolone. The Turing Foundation is contributing €350,000 towards this research (€25.000 in 2024).
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Randomised controlled trials of methotrexate in Erythema Nodosum Leprosum | ||||||||
Unlocking knowledge on mangrove recovery, Guinea Bissau, Tanzania, Indonesia, Philippines, 2019-2023
Wetlands International is the global not-for-profit organisation dedicated to the conservation and restoration of wetlands, their resources and biodiversity. Wetlands International is one of the five founders of the Global Mangrove Alliance and aims to improve knowledge sharing about effective mangrove restoration. It is working with international, national and local partners on best practices, starting in Guinea Bissau, Tanzania, Indonesia and the Philippines. With these best practices they are helping governments create good mangrove policy at landscape level. This will be followed by developing a communication strategy to mobilise the global mangrove community, which will ultimately contribute towards more effective restoration of 30,000 hectares of mangrove area in ten countries. The Turing Foundation is contributing € 300,000 towards this project (of which € 30,000 in 2023).
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Passing on knowledge about mangrove restoration, Guinea-Bissau, Tanzania, Indonesia and the Philippines | ||||||||
IDRI: Integration of rapid diagnostic tests to facilitate earlier diagnosis and simplified case management of Leprosy, 2018-2019
The Infectious Disease Research Institute (IDRI) is doing research on the island of Cebu in the Philippines into the effectiveness of two new leprosy tests. The project aims to detect leprosy at an early stage in leprosy patients' contacts and to better monitor the progression of the disease in leprosy patients being treated. In the earlier phase of the study, blood was collected from leprosy patients and their contacts using a finger prick. This group is being followed and screened for a period of 4 years. The Turing Foundation already contributed €140,000 towards the earlier phase of this research and is contributing €55,988 towards the final phase (2018-2019).
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IDRI: Integration of rapid diagnostic tests to facilitate earlier diagnosis and simplified case management of Leprosy | ||||||||
Scaling up capabilities for Effective rehabilitation and conservation of mangroves, Philippines, 2016-2018
The Zoological Society of London (ZSL) connects science, nature conservation organisations and people on the ground in order to contribute as effectively as possible to nature conservation. It has conservation projects in more than 50 countries, including since 2007 the Philippines. Since super-typhoon Haiyan in November 2013, there has been increased interest in mangroves and coastal protection in the Philippines. In 2014/2015 the Turing Foundation supported ZSL's training programme to accelerate the transfer of knowledge about proven effective restoration and protection methods. In 2016 ZSL wants to further increase capacity in the Philippines by training an additional 300 trainers and increasing national awareness of the importance of mangroves. This will be done by means of research and raising awareness by organising a third national conference and giving an 'award' for the best mangrove forest. The Turing Foundation is donating € 165,000 to this project (about 50% of the total budget, of which € 50,000 in 2018).
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Scaling up capabilities for Effective rehabilitation and conservation of mangroves, Philippines | ||||||||
Mangrove Rehabilitation, Verde Island Passage, Philippines, 2014-2017
For more than 25 years Conservation International (CI) has been doing valuable work protecting the environment, and involving politicians, policy makers, business and society in these efforts. CI wants to restore mangroves in cooperation with the local Filipino population. In response to new opportunities, CI revised its plan in 2018 and the goal will be to create a 'Green Wall of Mindoro'. CI wants to create a green coastal strip of mangrove swamps and forests extending 100 metres inland along Mindoro's 100 km northern coast and in a second phase the 240 km eastern coast. The Turing Foundation is contributing €320,000 towards the work on Mindoro (of which €100,000 in 2017). In the first phase, 300 ha of mangrove is being replenished and the management of 2,392 ha in twelve communities is being improved. Update januari 2019: The 'Green Wall Center' in Silonay, Calapan has been launched, and the provincial government has made concrete commitments. This is the 'hub' for the entire area and is an example for other communities. The ecological park now has protected status, a newly established nursery, income-generating activities and is managed by a trained local team.
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Restored mangroves around a shrimp farm in Batangas, Verde Island Passage, Philippines | ||||||||
IDRI: Integration of rapid diagnostic tests to facilitate earlier diagnosis and simplified case management of Leprosy, 2015-2017
The Infectious Disease Research Institute (IDRI) does research into improving the early diagnosis of leprosy patients in Cebu City in the Philippines. An easily usable test was recently developed which can detect leprosy in blood and/or serum, enabling patients to be diagnosed more quickly. Blood samples from these patients are examined and used together with the results of the clinical trials as a benchmark for the diagnosis and treatment process. The Turing Foundation is contributing €140,000 in the period 2015 - 2017 to this project (of which, €51,000 in 2017). The Leprosy Research Initiative (LRI) is contributing the same amount.
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IDRI: Integration of rapid diagnostic tests to facilitate earlier diagnosis and simplified case management of Leprosy, 2015-2017 | ||||||||
Research on treatment of early neuropathy in leprosy 2014-2017
The TENLEP Research Consortium (Treatment of Early Neuropathy in Leprosy) is a large international association in which 14 researchers from renowned research institutes all over the world work together, combining their expertise in the field of leprosy-related inflammation of the nerves. TENLEP Trial is a large-scale research project focussing on nerve damage caused by leprosy. Its central research questions are: 2. What is the most effective treatment for patients who have a clinical nerve function impairments?
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Scanning Electron Microscopy of M. leprae | ||||||||
Research into macro- and micro-epidemiology of leprosy 2014-2016
The Leonard Wood Memorial Research Centre in Cebu, Philippines, is conducting research into the transmission patterns of leprosy. In many areas, the transfer of leprosy seems to continue despite years of successful MDT (Multi-Drug Treatment) for lepers. The study's hypothesis is that effective leprosy control can be developed only with a better understanding of the transmission patterns within communities, and the identification of people with an increased risk of developing leprosy. Only then, interventions like chemoprofylaxe and/or immunoprofylaxe can be distributed properly and be cost-effective. Main goal of the research is to map all known cases of leprosy in Cebu in both space and time, and add all new cases of leprosy to the database (macro-epidemiology). Then, the database should be expanded with the M.leprae strain typing within the clusters of the new cases (micro-epidemiology) to reach a better understanding of the disease's transmission patterns, its risk factors and the virulence patterns of the M.leprae strains. The detailed mapping of cases of leprosy combined with the strain typing that should enable the identification of transmission patterns within a properly demarcated area has never before been attempted. De Turing Foundation contributed € 118.500 to the previous phase of this long-range study and will contribute another € 132,000 in the coming years (€ 45,000 of which will be donated in 2016).
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Skin infected with leprosy | ||||||||
Effective restoration of mangroves, Philippines, 2014-2015
In addition to two major zoos, the Zoological Society of London (ZSL) has a renowned science and conservation department. There has been increased interest in mangroves and coastal protection in the Philippines since typhoon Haiyan in November 2013. For this reason, ZSL wants to accelerate the transfer of knowledge about proven effective methods to restore and protect mangroves by, among other things, organising a training programme for 100 trainers and a national conference on the subject. Two coastal areas on the island of Panay are being established as demonstration sites, where knowledge can be applied in practice and the results can be directly monitored. In 2014 the Turing Foundation is contributing € 70,000 towards the training of trainers and knowledge transfer to stakeholders, in order to effectively restore the Philippines' mangroves.
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Supporting effective recovery of mangroves, Philippines | ||||||||
Research into macro- and micro-epidemiology of leprosy 2010-2013
The Leonard Wood Memorial Research Centre in Cebu, Philippines, is conducting research into the transmission patterns of leprosy. In many areas, the transfer of leprosy seems to continue despite years of successful MDT (Multi-Drug Treatment) for lepers. The study's hypothesis is that effective leprosy control can be developed only with a better understanding of the transmission patterns within communities, and the identification of people with an increased risk of developing leprosy. Only then, interventions like chemoprofylaxe and/or immunoprofylaxe can be distributed properly and be cost-effective. Main goal of the research is to map all known cases of leprosy in Cebu in both space and time, and add all new cases of leprosy to the database (macro-epidemiology). Then, the database should be expanded with the M.leprae strain typing within the clusters of the new cases (micro-epidemiology) to reach a better understanding of the disease's transmission patterns, its risk factors and the virulence patterns of the M.leprae strains. The detailed mapping of cases of leprosy combined with the strain typing that should enable the identification of transmission patterns within a properly demarcated area has never before been attempted. The Turing Foundation will contribute € 118,500 to this long-range study (€ 43,000 of which will be donated in 2012).
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Skin infected with leprosy | ||||||||
Protecting Endangered Turtles, Coral Triangle, 2012
Six out of the seven species of sea turtles we have on this earth live in the Coral Triangle. The animals are threatened most by the accidental bycatch of fishermen and by the loss of breeding habitat along the coasts. These majestic animals do not only play a principle role in the tourist industry; they also have an important symbolic meaning in initiatives and fundraising related to the protection of the Coral Triangle. The main purpose of this World Wildlife Federation project is to make certain that half of all migration routes, feeding areas and breeding habitats of sea turtles have a protected status by 2011. Moreover, WWF intends to halve the fishery bycatch of turtles, for example by distributing more than 300,000 circle hooks among the fisher fleet for the prevention of bycatch. The Turing Foundation will contribute € 250,000 to this project.
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Protecting Endangered Turtles | ||||||||
Sustainable Finance for Networks of Marine Protected Areas, Coral Triangle, 2012
The World Wildlife Federation has established a foundation for the identification and management of protected marine areas in the Coral Triangle, which consist of 50,000 km2 of coral reefs, 50,000 km2 of mangrove forests, and breeding grounds and migration routes of important fish species in 500,000 km2 of open water. The foundation helps to bridge budget gaps, until the local governments have their financial situations in order. The foundation is also able to offer immediate help should there be urgent needs in the protected areas. The Turing Foundation contributes € 600,000 to this foundation.
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A 1.5 metre Napoleon fish. These special coral fish are captured alive and then kept in the aquaria of very chic restaurants. Sometimes ten thousand square metres of coral are poisoned by cyanide to stun just one fish, after which the divers haul the stunned animal up between the coral into a mobile aquarium. | ||||||||
Live Reef Fish Trade Transformation, Coral Triangle, 2012
This World Wildlife Federation programme intends to achieve a recovery of the diverse fish population in the Coral Triangle, and a reduction of destructive fishing methods (such as dynamite fishing). One of the actions is the establishment of a Trade Association in the fishing industry (especially in Hong Kong) to promote sensible trade in the species of fish concerned. Simultaneously, plans will be made to encourage consumers to buy only fish that has been MSC certified. The Turing Foundation will contribute € 300,000 to the programme, which will run until 2012.
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Analysis of Live Reef Fish Trade routes in the Coral Triangle | ||||||||
Carbon footprint reduction and Protection of Critical Reefs, Coral triangle, 2012
We're approaching the final phase of our support of the Coral Triangle Initiative through the World Wide Fund for Nature. One of the final projects concerns the CO2-reduction and preservation of critical coral reefs. Within the Coral Triangle, the creation of Marine Protected Areas is not developing fast enough for the urgent need for breeding areas for fish and other life forms inhabiting and surrounding the coral reefs. Especially 'no-take zones', areas in which a total fishing ban is in effect, are a long time coming, although nature-preservation results and fishermen's fish stock in neighbouring areas are spectacular. It's why we've decided to do an extra investment for the project's final phase. In total, the Turing Foundation will be donating € 300,000 to this initiative.
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Bleached Coral Reefs, Coral Triangle | ||||||||
Seafood Savers Platform for Sustainable Tuna and Live Reef Fish, Coral Triangle, 2012
We're approaching the final phase of our support of the Coral Triangle Initiativethrough the World Wide Fund for Nature. One of the final projects is the setting up of a platform for sustainable tuna fishing. The yet to be founded 'Seafood Savers Platform' will bring together all important players in the field: fisheries, buyers, and retailers. The project also wants to generate a greater demand for sustainable fish products from WWF's small-scale field projects. In total, the Turing Foundation will be donating € 300,000 to this initiative.
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Fishing with dynamite, Coral Triangle | ||||||||
Responding to Climate Change through reduction of Tourism and travel footprint, Coral Triangle, 2007-2011
Global warming is bad for coral reefs - the corals will bleach, lose all their colour and eventually die. This is at the expense of marine life; it will limit fishing opportunities and reduce opportunities for tourism (which is an important source of income and an important stimulus for the protection of the corals). The World Wildlife Federation believes it is possible to help the coral reefs in the Coral Triangle by avoiding any further negative impact of climate change, by reducing other disturbing effects on their health (such as polluting industries, tourism and fishing). The Turing Foundation will contribute € 600,000 to this initiative, which will run until 2011.
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Responding to Climate Change through reduction of Tourism and travel footprint | ||||||||
Managing Tuna nurseries and bycatch, Coral Triangle, 2007-2011
Tuna fishing yields food and income for tens of millions of people living in the Coral Triangle. Besides, tuna plays a crucial role in the ecology of the coral reefs. The governments in the Coral Triangle acknowledge that their fishing areas can be continuous sources of food and income, as long as they are managed in the right way. Therefore, they have laid down laws for the sustainable use of these areas. However, structural overfishing has been taking place during the past twenty years. The World Wildlife Federation, together with the business community and the government, will design strategies and solutions to prevent the loss of tuna production in the Coral Triangle. The Turing Foundation will donate € 650,000 to this initiative, which will run until 2011.
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Managing Tuna nurseries and bycatch | ||||||||
Computer lessons, Philippines, 2007-2009
Zone One Tondo Organisation (ZOTO) is a popular movement, established in 1970, which offers help to the poor people of the Philippines between 10 and 24 years of age, in various fields: from education to technical support or financial support for the costs of living. The Turing Foundation paid for the computer equipment, and finances ZOTO computer courses for 300 young people until the end of 2009 (€ 36,000 in total). students of the computer courses 2008 | ||||||||
Ecosystem Management for the Murciellagos Bay, Philippines, 2007-2009
Murciellagos Bay is a breeding ground of important and diverse ecosystems. The bay covers 8,000 hectares and is home to rare and endangered fish, shellfish and sea turtle species. The area is threatened by pollution, overfishing and destructive fishing. The Philippine organisation PARTS (Partner for Rural & Technical Service) tries to have part of the coral reefs, mangrove forests and sea grass beds identified as Marine Protected Areas, so as to stop illegal fishing practices and encourage the recovery of the ecosystem and fish stock. The ambition is to achieve a sustainable balance between nature conservation and the local economy, for instance by strengthening the fishing organisations in most of the 24 local fishing villages, and by investing in nature education for the local community. The Turing Foundation and IUCN Nederland will together contribute the sum of € 90,000 to this project, which runs until June 2009.
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Fishing village, Murciellagos Bay, The Philippines | ||||||||
Sustainable management of the biodiversity in the Lamit Bay, Philippines, 2007-2010
The Philippine organisation NSLC (Network of Sustainable Livelihoods Catalysts) is devoted to a sustainable conservation of Philippine nature. The rich biodiversity of Lamit Bay is threatened by commercial overfishing and dynamite fishing. The local community, dependent on fishing and on the cultivation of red seaweed, will cooperate in the protection of a network of 'no-take zones' covering 350 hectares (in the form of Marine Protected Areas). Expectations are that this protection of coral reefs, sea grass areas and mangrove forests will lead to the sustainable conservation of the entire bay (50,000 hectares). The training of the local community and the tapping of sustainable alternative sources of income play an essential role in this project. The Turing Foundation and IUCN Nederland will together contribute € 88,000 towards the costs of the project until July 2010.
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10% improved coral cover measured in Lamit Bay at the end of the project (july 2010) | ||||||||
€3.000.000 for the Coral Triangle Initiative 2007-2012
No place on earth has such great biodiversity as the Coral Triangle. The triangle covers almost 6,000,000 km2 and stretches out as far as Indonesia, the Philippines, Malaysia, Papua New Guinea, the Solomon Islands, East Timor and Brunei Darussalam. The triangle is a true nursery of the sea, being the home of 75% of all coral species and of more than 3,000 different fish species. The area is seriously threatened by a range of factors, such as overfishing, destructive fishing (for example by the use of dynamite and cyanide), global warming and pollution. Here, the World Wildlife Federation is setting up one of its largest and most ambitious projects ever, which aims to introduce a new, long term model for the sustainable management of this wildlife area - before the combination of threatening factors will have left a permanent mark on it, and on the millions of households that depend on it. The project requires a whole range of simultaneous initiatives that address the various threats. If organised in the proper way, the initiatives will reinforce each other. A specially formed Coral Triangle Team will coordinate the entire project, and will in the coming years revise the strategy if necessary - possibly by developing new initiatives. The eventual purpose of this project is to save the nurseries of the Coral Triangle, which are of vital importance to the conservation of a healthy ecosystem in the oceans and along the coasts of the Coral Triangle. In the six years to come, the Turing Foundation contributes € 3,000,000 in total to the six sub-initiatives that are part of the first phase of the programme. These six initiatives are described below.
A new foundation will be established for the identification and management of protected marine areas in the Coral Triangle, which consist of 50,000 km2 of coral reefs, 50,000 km2 of mangrove forests, and breeding grounds and migration routes of important fish species in 500,000 km2 of open water. The foundation helps to bridge budget gaps, until the local governments have their financial situations in order. The foundation is also able to offer immediate help should there be urgent needs in the protected areas. The Turing Foundation will contribute € 600,000 to this foundation.
Tuna fishing yields food and income for tens of millions of people living in the Coral Triangle. Besides, tuna plays a crucial role in the ecology of the coral reefs. The governments in the Coral Triangle acknowledge that their fishing areas can be continuous sources of food and income, as long as they are managed in the right way. Therefore, they have laid down laws for the sustainable use of these areas. However, structural overfishing has been taking place during the past twenty years. Together with the business community and the government strategies and solutions will have to be designed to prevent the loss of tuna production in the Coral Triangle. The Turing Foundation will donate € 650,000 to this sub-initiative, which will run until 2010.
This programme intends to achieve a recovery of the diverse fish population in the Coral Triangle, and a reduction of destructive fishing methods (such as dynamite fishing). One of the actions is the establishment of a Trade Association in the fishing industry (especially in Hong Kong) to promote sensible trade in the species of fish concerned. Simultaneously, plans will be made to encourage consumers to buy only fish that has been MSC certified. The Turing Foundation will contribute € 300,000 to the LRFTT-programme, which will run until 2010.
Six out of the seven species of sea turtles we have on this earth live in the Coral Triangle. The animals are threatened most by the accidental bycatch of fishermen and by the loss of breeding habitat along the coasts. These majestic animals do not only play a principle role in the tourist industry; they also have an important symbolic meaning in initiatives and fundraising related to the protection of the Coral Triangle. The main purpose of this sub-project is to make certain that half of all migration routes, feeding areas and breeding habitats of sea turtles have a protected status by 2010. Moreover, WWF intends to halve the fishery bycatch of turtles, for example by distributing more than 300,000 circle hooks among the fisher fleet for the prevention of bycatch. The Turing Foundation will contribute € 250,000 to this sub-project.
Global warming is bad for coral reefs - the corals will bleach, lose all their colour and eventually die. This is at the expense of marine life; it will limit fishing opportunities and reduce opportunities for tourism (which is an important source of income and an important stimulus for the protection of the corals). It is possible to help the coral reefs by avoiding any further negative impact of climate change, by reducing other disturbing effects on their health (such as polluting industries, tourism and fishing). The Turing Foundation will contribute € 600,000 to this sub-initiative, which will run until 2010.
The Coral Triangle Initiative is a dynamic programme. It can be expected that extra activities are needed in the years to come in order to guarantee the success of the total project. Extra budget is already being made available for such future activities. The Turing Foundation subscribes to this realistic viewpoint and commits € 600,000 support to these currently unnamed sub-projects.
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